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December 20, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHEMISTRY HIGHLIGHTS 2004
Key advances were made this year in areas ranging from biochemistry, drug research, and analysis to nanotech and inorganic chemistry.
STABILITY THEORY
Studies of conjugated polyynes yield unexpected results.
GENOME FINGERPRINT SCANNING
New bioinformatics tool finds region of genome most likely to have encoded unknown proteins.
MULTIDISCIPLINARITY
New buildings physically connect chemistry and other science departments as a way of fostering interaction.
December 13, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
MOLECULAR MAGNETS
Single-molecule magnets offer much potential in growing area of materials research.
NEW PRODUCTS
New And Notable In The Chemical Industry.
December 6, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
HEAD OF THE LAB
Analytical Laboratory Managers Association celebrates 25th anniversary.
SIR DAVID KING
Britain's chief scientific adviser has raised the profile of science in government.
November 29, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CATALYST DESIGN
Advanced computational methods guide modern catalysis research.
RIBOSOMES
Several research groups work to clarify the underlying mechanism of the ribosome.
INSIGHT
It might be time to move on from the theme of chemistry as the central science.
DIGITAL BRIEFS
New Software And Websites For The Chemical Enterprise.
November 22, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
METABOLIC SYNDROME
Complex set of disorders offers drug development opportunities; a new NMR technique measures low-density lipoproteins.
PLAYING AROUND
High-quality musical instruments need high-quality materials.
WELCH FOUNDATION
Chemical research in Texas has benefited mightily from 50-year-old endowment.
SEPARATION SCIENCE
Ultra-high-pressure chromatography helps researchers achieve the once impossible.
NEW PRODUCTS
New And Notable In The Chemical Industry.
November 15, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ACADEMIC R&D
Latest NSF data from 2002 show marked growth in funding for chemical research.
MASS SPEC IMAGING
Pictures of spatial distribution of specific molecular components can be used for medical and biological applications.
THEORY IN TRANSITION
Studies of formaldehyde decomposition suggest that some reactions can sidestep the transition state.
November 8, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
IONIC LIQUIDS
Designer solvents find diverse uses in organic synthesis.
VISIONS OF SCIENCE
Breathtaking images of science are honored in annual photo competition.
WHAT'S THAT STUFF?
Physical chemistry and flavor-release techniques make ice cream a favorite treat.
November 1, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHEMISTRY NOBELS
Laureates recount the paths that led to their prize-winning ubiquitin findings.
PHYSICS NOBELS
Quark work was a major step in the quest for a comprehensive theory of physics.
ANTIVIRAL MECHANISM
Researchers identify the binding site of a nonpeptide small-molecule drug that inhibits viral fusion with cell membranes.
October 25, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DIABETES DRUGS
Treatment paradigm involving peptide hormone receptor promises new hope for therapy.
IMAGING STUDIES
Fluorescent tags and quantum dots shine light on cellular processes.
MOLECULAR MACHINES
European conference focuses on how to move systems from lab curiosities to components in useful devices.
INSIGHTS
One doesn't have to be a dyed-in-the-wool chemist to win the Nobel Prize in Chemistry.
October 18, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
POINT-COUNTERPOINT: CHLORINE
C. T. Howlett Jr. and Terrence Collins debate chlorine's positive and negative contributions.
CHEESE FLAVORS
Complexity of flavors comes from a multitude of chemical components.
SOUTHERN RESEARCH INSTITUTE
Organization is a leader in anticancer drug development.
ACTINIDE ACTION
Novel thorium and uranium complexes aid understanding of f-element electronic structure and reactivity.
NEW PRODUCTS
CRITTER CHEMISTRY
Shrew saliva yields some surprising compounds.
October 11, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
MICROCHANNELS
Reactors with parallel microscale channels offer commercial benefits.
NITROGEN QUEST
Two approaches may lead to solid all-nitrogen compounds at room temperature and pressure.
PYRROLYSINE
Studies show the 22nd amino acid is biosynthesized directly.
JANELIA FARM
Institute is recruiting chemists for collaborative interdisciplinary projects.
October 4, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
COMBICHEM
Modeled after natural products, diversity-oriented synthesis gives hope to a field in need of a boost.
PRINTING POLYMERS
Ink-jet printers transform into fast, flexible instruments for making libraries of polymer thin films.
DRUGS IN THE ENVIRONMENT
Household chemicals are entering U.S. drinking water and pose complex issues of toxicity and removal.
September 27, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
HIGH-PERFORMANCE COMPUTING
Demand for computers of all sizes and designs is continually increasing for all kinds of problems in chemistry.
NANOSCALE
Researchers work to understand how catalytic properties of solids change with size.
NANOCATALYSTS
Panel addresses the novelty and importance of nanotechnology in catalysis.
NATURAL PLASTIC
New model sheds light on how bacteria synthesize polyesters.
INSIGHTS
Chemistry plays both good and bad roles in the arena of performance-enhancing drugs.
DIGITAL BRIEFS
New Software And Websites For The Chemical Enterprise.
September 20, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
STRUCTURAL PROTEOMICS
Biotechnology companies try to meet demand for contract research in this dynamic market.
PRIESTLEY BICENTENNIAL
Multiple ACS national meeting events focused on the discoverer of oxygen and other gases.
YOUNG INNOVATORS
Forum features research contributions of talented young chemists working in industry.
AGROCHEMICALS
Numerous hurdles keep many promising pesticide candidates from reaching the market.
WHAT'S THAT STUFF?
Plastic bags possess different properties depending on the type of polyethylene used in their manufacture.
September 13, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
PERKIN MEDAL
Intel cofounder Gordon Moore receives SCI's highest honor.
AMINO ACID SYNTHESIS
With the right catalyst, unprotected enamines are good substrates for enantioselective synthesis.
MEETINGS BRIEFS
NEW PRODUCTS
New And Notable In The Chemical Industry
September 6, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
FINE CHEMICALS
Suzuki coupling and related chemistries gain ground in commercial practice, from small-scale synthesis to industrial-scale production.
FOWL CHEMISTRY
Researchers use chicken feathers to make a variety of products, including films, composites, and plastics.
ORGANOCATALYSIS
Small-molecule organic catalysts both eliminate the need for metals and catalyze reactions not thought possible.
FUTURE CHEMISTS
Focus groups reveal youngsters' attitudes about chemists and chemistry.
August 30, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ADVANCED COMPOSITES
By blending distinct components, researchers make materials for auto, aerospace, defense, and other industries.
MACARTHUR FELLOWS
Three women chemists thrived during their five-year fellowships.
TALE OF A TOXIN
Chemists revise structure and synthesize elusive marine toxin.
INSIGHTS
When it comes to injury on the job, grad students' status is murky.
DIGITAL BRIEFS
August 23, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
AGING
Scientists attempt to understand the triggers, timing, and molecular basis of this inevitable condition.
PIONEERING THE PERIODIC TABLE
A personal collection turns into a quest to rediscover the elements.
August 16, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
NANOTUBES
Cylinders of multiwalled carbon nanotubes could provide easy-to-make, easy-to-clean, reusable filters.
WHAT'S THAT STUFF?
Margarine owes its spreadability to partially hydrogenated fatty acids.
NEW PRODUCTS
August 9, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CARBOHYDRATE VACCINES
Novel techniques for constructing and synthesizing antigenic carbohydrates are making possible a new generation of vaccines.
OLYMPIC GAMES
Athens drug-testing lab is ready to monitor athletes to ensure fair competition.
RNA INTERFERENCE
Messenger RNA-cleaving protein is identified.
August 2, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DATA SHARING
Efforts under way will establish standards for DNA microarray data.
BIOLOGICAL CLOCKS
Three cyanobacteria protein structures lead toward an understanding of cell timekeeping.
July 26, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
NOVEL VARIATION
Bacterial pathogen's unique version of a key enzyme might help evade the chemical defenses of hosts.
INSIGHTS
Worries about self-replicating machines running amok, the "gray goo problem," are unfounded.
DIGITAL BRIEFS
New Software And Websites For The Chemical Enterprise
July 19, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ROBERT DYNES
New president of the University of California must tackle budget cuts with increased enrollment.
VISION RESEARCH
Regulatory "switch" plays a crucial role in how we see.
NEW PRODUCTS
New And Notable In The Chemical Industry
July 12, 2004
GREEN CHEMISTRY HONORS
Presidential honors recognize innovative chemical products and processes that prevent pollution.
SCIENCE/TECHNOLOGY CONCENTRATES
PROTEOMICS
Technique may permit more widespread use of mass spec for protein sequencing.
DRUG DISCOVERY
DNA display technique offers a new approach to synthesizing organic compound libraries.
DESIGNING ENZYMES
Using computational design and directed evolution, researchers created an enzyme from a receptor protein.
July 5, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
RNA INTERFERENCE
New mechanistic insights may help improve this biologically important tool.
MICROREACTORS
Technology allows precise reaction control, better product quality control for fine chemicals.
HOST-GUEST BEHAVIOR
Supramolecular interactions in the gas phase can be studied using tandem mass spectrometry.
CRITTER CHEMISTRY
For the Heliothis subflexa caterpillar, picky eating makes perfect sense.
NICKEL-BASED CATALYST
Structural images show how a novel superoxide dismutase sops up harmful radicals.
June 28, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DRUG DISCOVERY TOOLBOX
What's useful, what's needed are among issues aired by both industry and academia at Horizon Symposium.
SPACE EXPLORATION
NASA Cassini spacecraft is set to begin four-year probe of Saturn.
DIVERSITY AT HUNTER
College serves as a model for supporting women and minorities in the sciences--both faculty and students.
INSIGHTS
Consequences of climate change may be devastating by century's end.
DIGITAL BRIEFS
June 21, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CATCHING UP
Seven professors profiled by C&EN in 2000 reflect on their progress.
MITOCHONDRIAL DNA
Latest research challenges the notion that this DNA is inherited solely from the mother.
WHAT'S THAT STUFF?
No-calorie sugar substitutes have sweetening powers hundreds of times that of sucrose.
NEW PRODUCTS
June 14, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHIRAL CHEMISTRY
Traditional methods still dominate, with few catalytic enantioselective processes currently operated on a commercial scale.
IRELAND INVESTS IN TOP-CLASS SCIENCE
Science Foundation Ireland programs are geared to biotechnology, information technology.
WORLDWIDE SCIENCE
Growth in scientific papers is mostly in Europe and Asia.
FLUORINE IN THE ENVIRONMENT
Polyfluorinated alcohols are the likely source of persistent and potentially toxic perfluorocarboxylic acids.
June 7, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHEMISTS OF THE CARIBBEAN
Chemistry in the West Indies flourishes despite infrastructure and funding issues.
ARNOLD BECKMAN APPRECIATION
His inventions propelled chemical research through the 20th century; his philanthropy will take it through the 21st.
TIDE RISES FOR ALABAMA CHEMISTRY
New research facilities and funding provide a boost for chemical research.
May 31, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
NAVAL RESEARCH LABORATORY
Research center has made numerous advances reaching from land to sea, air, and space.
INDUSTRIAL BIOTECH
Conference highlights challenges required to produce chemical feedstocks from renewable resources.
HEPTAZINES
Odd family of nitrogen-rich molecules is enjoying a renaissance, thanks to its potential in creating carbon nitride materials.
May 24, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CERAMICS AT ALFRED UNIVERSITY
Alfred is a locus for world-class glass and ceramics research and art.
OUTSMARTING HIV
New research examines how some drugs evade the virus's resistance mechanisms.
DIGITAL BRIEFS
New Software And Websites For The Chemical Enterprise.
May 17, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DRUG SAFETY
Predicting toxicity early in the drug development process remains a challenge.
PROCESS ANALYTICAL CHEMISTRY
Center celebrates 20 years of methods to improve efficiency of manufacturing processes.
WATER CLUSTERS
IR spectra reveal details about species that may help clarify atmospheric processes, hydrogen bonding, and other water interactions.
May 10, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
MAIN-GROUP REVIVAL
ACS symposium highlights new developments in the resurgent field of main-group chemistry.
FIRST-TIME DISCLOSURES
Researchers from major pharmaceutical companies introduce new drugs at ACS symposium.
FLEXIBLE RECEPTORS
Docking programs can overlook important potential drug candidates because of flexibility of the protein itself.
NEW PRODUCTS
May 3, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DESIGNER LIQUIDS
Ionic liquids find diverse applications in polymer science.
CHEMISTRY OF CHOLESTEROL
Lipid plays a crucial role in cell membranes.
SILKEN SECRETS
New model for protein assembly is based on silkworm cocoons.
April 26, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CARBOHYDRATE CALCULATIONS
Despite their complexity, carbohydrates are finally yielding to the power of computational chemistry.
BACTERIAL CELLULOSE
Fiber's unique properties lead to potential use in electronic paper and wound care.
WHAT'S THAT STUFF?
Kitty litter choices range from simple clays to silica gels to plant-derived alternatives.
ARNOLD L. RHEINGOLD
Prolific crystallographer has produced some 6,000 crystal structures.
DIGITAL BRIEFS
ETHICS EDUCATION
Colleges make an effort to fit research ethics into the curriculum.
April 19, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ORGANOZIRCONIUM CHEMISTRY
On its golden anniversary, the field finds wide application in organic synthesis.
CIRCULAR AND KNOTTED PEPTIDES
Compounds discovered in bacteria, plants, and animals are stable and resistant to chemical, thermal, or enzymatic degradation.
MEETING BRIEFS
April 12, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
NANO REVOLUTION
The ultrasmall makes a big splash at ACS national meeting.
ART AND HAZARDS
Health and safety instruction now form part of an artist's education
ALDOL REACTION
Researchers develop first step in two-step route for making simple carbohydrates.
NEW PRODUCTS
April 5, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
THINKING GREEN
Benign and sustainable chemistry is on the minds of many in the U.K.
HISTONE PROTEOMICS
Researchers use a mass spectrometer and database searching to characterize intact proteins.
WHAT'S THAT STUFF?
Special adhesive developed by 3M has led to ubiquitous and indispensable sticky notes.
March 29, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
2004 PRIESTLEY MEDALIST
Nobel Prize winner E. J. Corey is honored for his profound contributions to organic chemistry and biomedical sciences.
PITTCON 2004
Marked by an improved business climate and increased attendance, this year's show highlighted innovative products and covered advances in research on breath analysis, aptamers, ancient DNA, and more.
INSIGHTS
Emotions and beliefs can affect our objective judgment based on sound science.
March 22, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ION CHANNELS
Conflicting research findings on the mechanism of voltage-gating in K+ channels has caused controversy.
D-FREE SPECTRA
1H NMR technique uses nondeuterated organic solvents.
DIGITAL BRIEFS
March 15, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHIRAL CATALYSIS
New insights into asymmetric surface chemistry may lead to large-scale applications.
OLEFIN TAILS
Anti-Markovnikov reactions are being developed to add terminal functional groups to alkenes.
NEW PRODUCTS
March 8, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
NITRIC OXIDE'S NEW PLAYER?
Researchers explore the chemistry of NO's biological alter ego, HNO.
TISSUE ENGINEERING
To grow large tissues, such as vital organs, the problem of vascularization must be solved.
EDUCATION
Fewer undergraduates seek degrees in chemical engineering.
WOMEN IN ACADEMIA
NSF's Advance program works to bring more women into leadership roles.
March 1, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DRUG DELIVERY
Companies emphasize products over platforms and are positioning their technologies earlier in the drug development timeline.
BORON: ANYTHING BUT BORING
Chemists and physicists explore planar all-boron clusters.
DISCODERMOLIDE
Marine natural product that inhibits tumor cell growth is synthesized industrially.
NANOSTRUCTURED RESINS
Researchers have prepared catalysts that outperform their amorphous resin counterparts.
February 23, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
ATTRACTED TO ZURICH
Research support, infrastructure, opportunities for industrial collaboration, and long-standing chemical tradition lure U.S. chemists.
ENZYME MECHANISMS
New proposals and insights provoke debate and controversy over transition-state theory.
INSIGHTS
Robotic exploration of the solar system is just as exciting as sending humans to do the job, and makes a lot more sense.
NEW PRODUCTS
February 16, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
MOLD RISKS
There is growing concern over the health effects of indoor mold, and current building design and materials may be partly to blame.
NOVEL CHEMISTRY
At Informex, K. Barry Sharpless talked about click chemistry--a new approach to organic synthesis that's inspired by nature.
DIGITAL BRIEFS
February 9, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DEPRESSION
Although depression is not completely understood, great strides have been made with various pharmaceuticals to treat this multifaceted disorder.
BIOCATALYSIS
The application of enzymatic processes to polymer science yields promising new materials.
COMPUTATIONS
Established statistical method makes calculating vibrational spectra of molecules quicker and more accurate.
February 2, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
DIAMOND SYNTHESIS
Man-made gem is more than just another pretty face; its remarkable properties offer much for materials applications.
DNA ALKYLATION
New approach could sidestep problems with current strategies.
January 26, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
CHANNELS EXPLAINED
New theories emerge about how aquaporins block the passage of protons.
JENNIFER HOLMGREN
C&EN talks with UOP's research director, who believes that innovation brings growth.
NEW PRODUCTS
January 19, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
BIOACTIVE AGENTS
Peptide analogs with attached identity tags are pursued for diagnostic, therapeutic, and catalytic applications.
MERCURY TOXICOLOGY
Biotoxicity of Hg compound stems from its biomolecular mimicry.
WHAT'S THAT STUFF?
Techniques for making or faking snow provide year-round fun.
DIGITAL BRIEFS
January 12, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
RENDEZVOUS IN THE MEDITERRANEAN
Chemistry symposium in Malta promotes cooperation in troubled Middle East
CRITTER CHEMISTRY
The homely naked mole-rat may prove attractive for pain research.
January 5, 2004
SCIENCE/TECHNOLOGY CONCENTRATES
MATERIALS RESEARCH
Topics at annual meeting include nanostructuring, biomaterials, nanotubes, and hydrogen-storage materials.
SUSTAINABILITY
EPA student competition spotlights need for green products and processes.
WHAT'S THAT STUFF?
Champagne's characteristic effervescence is caused by fermentation and governed by Henry's law.
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